Refludan                    
Drip Information  
   
No Renal Impairment: 0.4mg/kg bolus, then 0.15mg/kg/hr  
CrCl 45-60: 0.2mg/kg, then 0.075mg/kg/hr  
CrCl 30-44: 0.2mg/kg, then 0.045mg/kg/hr  
CrCl 15-29: 0.2mg/kg, then 0.0225mg/kg/hr  
CrCl < 15: Avoid use  
Doses based on weight up to 110kg  
                     
aPTT ratio (aPTT/midpoint of lab normal range) target is 1.5-2.5  
aPTT should be checked every 4 hours until aPTT ratio 1.5-2.5  
If aPTT ratio < 1.5, increase dose by 20%    
If aPTT ratio > 2.5, decrease dose by 50%    
   
Initiation of Drip (0.4mg/ml)
Kg Pounds
 
Weight:  
CrCl: ml/min    
Bolus: mg = ml given over 15-20 seconds (bolus should be 5mg/ml)  
Infusion Concentration mg/ml    
Infusion Rate: ml/hr    
Infusion Dose: mg/kg/hr    
   
Use aPTT lab normal range to determine aPTT reference Choose your own exact aPTT reference Dosage Adjustments    
        OR  
   
aPTT lab normal range: to seconds or use seconds  
aPTT reference: seconds     
Target aPTT level: to seconds  
aPTT measured: seconds    
aPTT ratio:    
Current Rate: ml/hr                               
New Rate: ml/hr  
Next aPTT due: