| Information on Various Drips and other
Injectables |
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| Alphabetized by Brand Name |
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| A
B C D E F G H I J K L M N O P Q R S T U V W X Y Z |
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| 1/4 Normal Saline |
Water 1000ml + 23.4%
NaCl (4meq/ml) 38.8meq (9.7ml) |
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| D12W 500ml |
D10W 500ml + 26.32ml of D50 |
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| Abelcet (Amphotericin B Lipid
Complex) |
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***Protect from Light*** |
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Mix in D5W |
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***Do not mix in any
electrolyte solutions*** |
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Adult Dose: 5mg/kg q24 |
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Adult Concentration: |
0.16-0.83mg/ml |
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Neonatal Dose: |
1-5mg/kg, Start at
1mg/kg |
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May increase in daily
1mg/kg increments |
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Neonate Conc.: |
1-2mg/ml |
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Rate = 2.5mg/kg/hr i.e. run over 2 hours |
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Stable for 48 hours
under refrigeration plus an additional 6 hours at room temp. |
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Dosing Calculator |
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| Acetadote (Acetylcysteine for Tylenol
overdose) |
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150mg/kg in 200ml
D5W over 15 minutes |
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50mg/kg in 500ml D5W
over 4 hours |
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100mg/kg in
1000ml D5W over 16 hours |
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Dosing Calculator |
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Dosing
Protocol |
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| Activase (Alteplase) |
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Dilute 50mg vial with
50ml or 100mg vial with 100ml of sterile water to make 1mg/ml |
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Must be used within 8
hours of mixing |
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Dosing: |
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(TIA) - 0.09mg/kg
over 1 minute, then 0.81mg/kg over 1 hour (maximum total of 90mg) |
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(Arterial thrombosis)
0.05-0.1mg/kg/hr over 1-8 hours |
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(PE) 100mg IV over 2
hours or 30-50mg via pulmonary artery over 1.5-2 hours |
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(MI: 3 hr infusion)
0.75mg/kg over 1 hour, then 0.25mg/kg/hr x 2 hours (If BW < 65kg) |
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(MI: 3 hr infusion)
60mg over 1 hour, then 20mg/hr x 2 hours (If BW > 65kg) |
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(MI: accelerated
infusion) 15mg over 1-2 minutes, then 0.75mg/kg (max 50mg) over 30
minutes, |
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then 0.5mg/kg (max
35mg) over 1 hour |
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(Prevention for
reocclusion Post-MI) 3.3mcg/kg/minute x 4 hours |
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Dosing Calculator |
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| Aminocaproic acid |
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Stable in dextrose and NaCl |
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Stable for at least 7 days |
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10-100mg/ml
concentrations have been used |
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Manufacturer
recommends diluting to approximately 20mg/ml or 50ml of diluent for each
gram of drug |
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For acute bleeding
syndromes manufacturer recommends 4-5gm over 1 hour |
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followed by 1gm per hour for about 8 hours or
until bleeding is controlled. |
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Maximum daily dosage: 30 grams |
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| Ambisome (Amphotericin B Liposome) |
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***Protect from Light*** |
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Mix in D5W |
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***Do not mix in any
electrolyte solutions*** |
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4mg/ml concentration
made by adding 12ml sterile water to 50mg vial (stable for 24 hours), |
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then further dilute
for infusion (stable for 6 hours) |
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Must be refrigerated |
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Adult Dose: 3-5mg/kg q24 |
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Adult Concentration: |
1-2mg/ml |
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Neonatal Dose: |
1-5mg/kg, Start at
1mg/kg |
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May increase in daily
1mg/kg increments |
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Neonate Conc.: |
Less than 2mg/ml |
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Rate = Run over 2 hours |
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Dosing Calculator |
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***Protect from Light*** |
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Mix in D5W |
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***Do not mix in any
electrolyte solutions*** |
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Adult Dose: 3-4mg/kg q24 |
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Adult Concentration: 0.16-0.83mg/ml |
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Neonatal Dose: 3-4mg/kg |
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Neonate Conc.: 0.16-0.83mg/ml |
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Rate = 1mg/kg/hr i.e.
if dose is 3mg/kg, run over 3 hours and 4mg/kg over 4 hours, etc |
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Rate may be shortened
to 2 hours if well tolerated |
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Test dose of 10ml to
be pulled from infusion bag should be given over 15-30 mintes, |
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then monitor patient
for 30 minutes for any reaction |
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Stable for 24 hours under refrigeration |
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Dosing Calculator |
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| Amphotericin B (Conventional Formulation) |
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***Protect from Light*** |
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Mix in D5W |
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***Do not mix in any
electrolyte solutions*** |
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Adult Dose:
0.25-1mg/kg q24 may be increased to 1.5mg/kg q48 |
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Total Daily dose
should NEVER NEVER NEVER exceed 1.5mg/kg |
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Adult Concentration: 0.1mg/ml |
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Neonatal Dose: 0.5-1MG/KG |
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Neonate Conc.: 0.1mg/ml |
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Run over 2-6 hours |
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Stable for 24 hours
at room temperature, 7 days under refrigeration
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Dosing Calculator |
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| Antizol
(Fomepizole) |
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Compatible with dextrose and NaCl |
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Stable for 24 hours |
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If drug becomes solid in vial,
hold under warm water to get drug to go back into solution |
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Mix in 100ml of fluid |
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Run over 30 minutes |
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Dose: 15mg/kg, then 10mg/kg q12
x 4 doses, then 15mg/kg until ethylene glycol or methanol level is less
than 20mg/dl |
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Dosing
Protocol |
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| Aredia (Pamidronate disodium) |
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Compatible with dextrose and NaCl |
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Stable under refrigeration for
24 hours |
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Dilute 30mg doses in 500ml of fluid |
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Dilute 60-90mg doses
in 1000ml of fluid |
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30-90mg to give over 2-24 hours |
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| Argatroban |
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Compatible with dextrose and NaCl |
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Treatment of HIT: Start with 2mcg/kg/min |
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Obtain a baseline
aPTT level,then Monitor aPTT levels until the |
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aPTT is 1.5-3 times
baseline value (obtain level every 2 hours) |
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Patients with moderate hepatic impairment
initiate with 0.5mcg/kg/min |
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Stable for 24 hours at room temperature, 48 hours
under refrigeration |
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Dosing Calculator |
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Dosing Protocol |
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| Azactam (Aztreonam) |
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Compatible with dextrose and NaCl |
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Should be given over
20-60 minutes per gram |
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Maximum concentration 1gm/50ml |
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Stable for 48 hours at room temp or 7 days under
refrigeration |
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| Bactrim (Sulfamethoxazole/TMP) |
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Mix in D5W |
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Stable for 4-6 hours |
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Dilute each 5ml of Bactrim in
125ml of Dextrose (75ml if fluid restriction) |
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Dose:
8-10mg/kg of TMP (0.5-0.625ml/kg) split q6, 8, or 12 |
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Available as Sulfamethoxazole 80mg/ml & TMP 16mg/ml
(dosing based on TMP) |
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Run over 60 - 90 minutes |
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| Bananna Bag |
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Compatible with dextrose and NaCl |
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Thiamine and folic
acid can be put in a piggy back |
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Multivitamins may be put in as little as 500ml, but 1000ml
is recommended. |
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Stable for 24 hours |
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| Brevibloc (Esmolol) |
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Compatible in dextrose and NaCl |
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Mix in D5W |
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Available as 10mg/ml premix |
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Stable when mixed for
7 days at room temperature or under refrigeration |
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Dosing
Protocol |
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| Calcium Gluconate |
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Stable for at least 24 hours |
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Compatible with dextrose and NaCl |
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May push undiluted or give as an infusion |
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Do not exceed 1.8meq/min (2-3
minutes per 10ml amp) |
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| Cancidas (caspofungin): |
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70mg load followed by 50mg/day |
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Mix in 250ml of 0.9% NaCl |
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***Unstable in dextrose*** |
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May be mixed in 100ml
if patient requires fluid restriction |
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In patients with
moderate hepatic insufficiency, dose may be 35mg |
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Run over 1 hour |
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Stable 24 hours out of fridge |
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Stable 24 hours out of fridge |
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| Cardene IV
(Nicardipine HCl) |
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Compatible in dextrose and NaCl |
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Dilute 25mg/10ml vial
with 240ml to make 0.1mg/ml infusion |
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Stable for 24 hours
at room temperature |
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NOT compatible with
Lactated Ringers or Sodium Bicarbonate |
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Dosing
Protocol |
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| Cardizem (Diltiazem) |
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Compatible in dextrose and NaCl |
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Put 125mg (25ml) in
100ml of fluid to make 1mg/ml |
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Stable for at least
48 hours under refrigeration |
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Dosing
Protocol |
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| Cerebyx (Fosphenytoin) |
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Compatible in dextrose and NaCl |
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75mg = 50mg PE (phenytoin equivalents) |
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Mix in concentration of 1.5-25mg/ml of PE |
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Run no faster than 150mg/min PE |
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Stable for 30 days
under refrigeration, 2 days at room temperature |
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| Cordarone (Amiodarone) |
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Mix only in dextrose,
it can precipitate in NaCl |
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Must be mixed in
glass if infusion exceeds 2 hours (i.e. a bolus can be put in a bag |
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Mix in concentrations of 1-6mg/ml |
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Concentrations
greater than 2mg/ml must be given via a central line |
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Stable for at least 5
days at room temperature |
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Must be administered
by a volumetric infusion pump *** NOT drop counter infusion sets |
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Dosing Calculator |
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Dosing Protocol |
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| Corlopram (Fenoldopam) |
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Compatible with dextrose and NaCl |
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Mix 10mg in 250ml to
make a final concentration of 40mcg/ml |
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Stable for 24 hours at room temperature |
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DO NOT USE A BOLUS |
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Dosing Calculator |
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Dosing
Protocol |
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| Cortrosyn (Cosyntropin) |
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May be given IM, IV push, or by IV infusion |
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If given IV push, silute 0.25mg vial with 1ml of
0.9% NaCl and push over 2 minutes. |
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For IV infusion, dilute in dextrose or saline and
give 0.25mg dose over 6 hours |
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Normal patients will
have a baseline cortisol level of greater than 5mcg/dL |
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and a level of 18mcg/dL with an increase of at
least 7mcg/dL 30 minutes |
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after recieving Cortrosyn. If the level is taken
60 minutes after recieving |
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Cortrosyn, there
should be an increase of at least 11mcg/dL. |
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Do not give Cortrosyn with blood or plasma
infusions due to enzyme degredation |
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Dosing
Protocol |
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| Corvert
(Ibutilide) |
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Compatible with dextrose and NaCl |
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Add drug to 50ml of
fluid and infuse over 10 minutes |
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Dose for Patients
60+kg: 1mg = 10ml (whole vial) |
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Dose for Patients
< 60kg: 0.01mg/kg = 0.1ml/kg of vial |
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Stable for 24 hours
at room temperature or 48 hours under refrigeration |
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Dosing
Calculator |
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Dosing
Protocol |
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| Demadex (Torsemide) |
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Compatible in dextrose and NaCl |
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Mix in dextrose at
concentration of 0.1-0.8mg/ml
OR |
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Mix in NaCl at
concentration of 0.1-0.4mg/ml |
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Stable for 24 hours at room temperature |
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| Digibind (Digoxin Immune Fab) |
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Dilute in 50-100ml of 0.9% NaCl and infuse over
at least 30 minutes; if infusion reactions occur, infuse slower |
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Infusion may be given wide open
if cardiac arrest is imminent |
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Infusion must be used within 4 hours of
reconstitution |
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Hypokalemia, rapid
ventricular response, CHF exacerbation, or low cardiac output may result
from digoxin withdrawal |
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Dilute vials with 4ml (each vial contains
38mg) |
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Dosing
Calculators |
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| Digifab (Digoxin Immune Fab) |
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Dilute in 0.9% NaCl to a concentration of
approximately 10mg/ml and infuse over at least 30 minutes |
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If infusion reactions occur, infuse slower |
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Infusion may be given wide open
if cardiac arrest is imminent |
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Infusion must be used within 4 hours of
reconstitution |
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Hypokalemia, rapid
ventricular response, CHF exacerbation, or low cardiac output may result
from digoxin withdrawal |
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Dilute vials with 4ml (each vial contains
40mg) |
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Dosing
Calculators |
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| Depacon (Valproate Sodium) |
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Compatible in dextrose and NaCl |
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Stable for at least 6 days at
room temperature |
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Dilute with at least 50ml of fluid |
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Run over 1 hour not to exceed
20mg/min (1.2gm/hour) |
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| Dilantin (phenytoin) |
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Should be given into
a large vein through large gauge needle or large catheter. |
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Rate should not exceed 50mg/min |
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May be given IV push
(preferred because it is not very stable in solution) |
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Can be mixed in NaCl
approximately 10mg/ml |
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| Dobutamine |
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Dobutamine is
available in 250ml bag of D5W at a concentration of 1mg/ml |
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Compatible in dextrose and NaCl |
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Stable for 24 hours at room temperature |
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Dilute to a
concentration of no greater than 5mg/ml |
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Dosing Protocol |
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| Dopamine |
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Dopamine is available
in 250ml bag of D5W at a concentration of 1.6mg/ml |
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Dosing
Protocol |
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| Epinephrine |
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***Protect from light*** |
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Compatible in dextrose and NaCl |
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Standard infusion is
4mg/liter, but much higher concentrations may be used (i.e.
87mg/liter). |
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Stable for at least
24 hours if protected from light. |
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Do not use if
solution appears pink (epinephrine is oxidized) |
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Dosing Protocol |
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| Ferrlecit (solium ferric gluconate complex): |
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Dose: 125mg in 100ml 0.9% NS |
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Run over 1 hour |
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NO test dose (that's with Iron Dextran) |
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| Infed (Iron
Dextran) |
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0.9% NaCl is the suggested
diluent for iron dextran |
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Using Dextrose had a greater
incidence of phlebitis |
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Stable for at least 3 months
under refrigeration |
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First, give a test dose of 25mg,
wait one hour, then give the remainder of the dose over one to six
hours |
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Dose in adults:
50*[0.0442*(Desired Hemoglobin - Actual Hemoglobin) * IBW + (0.26*IBW)] |
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| Inocor (Inamrinone) |
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Discard after 24
hours |
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Compatible with NaCl
(Do NOT mix in dextrose) |
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Dilute to
1.25-2.5mg/ml |
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Dosing
Protocol |
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| Integrilin Drip (eptifibatide): |
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Bolus: 180mcg/kg |
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Drip Rate: 2 mcg/kg/min |
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Drip
Concentration: 2mg/ml |
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If CrCl < 50ml/min, the rate is half with same
bolus |
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Available in 100ml premixed vial |
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Dosing Calculator |
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Dosing Protocol |
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| Isuprel
(Isoproterenol) |
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***Protect from light*** |
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Concentration
0.4-4mcg/ml (1-10ml of 0.2ml/ml injection in 500ml of fluid. |
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Compatible in dextrose and NaCl |
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Stable for at least
24 hours if protected from light. |
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Dosing
Protocol |
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| Levophed (Norepinephrine) |
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***Protect from light*** |
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Compatible in dextrose and NaCl |
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Must be given in a large vein |
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May be mixed at
4-40mcg/ml concentrations |
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4mcg/ml: 1 amp (4ml in 1000ml of fluid) |
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16mcg/ml: 1 amp (4ml in 250ml of fluid) |
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32mcg/ml: 2 amps (8ml in 250ml of fluid) |
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Dosing
Protocol |
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| Lidocaine |
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Available in a 2 gm in 500ml of
D5W as a premix |
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Compatible in dextrose and NaCl |
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| Magnesium: |
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Compatible in dextrose and NaCl |
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May be diluted to
concentration of 200mg/ml or less |
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Stable for at least
60 days under refrigeration |
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Maximum rate of
infusion is 150mg/min (i.e. 2 gm over 15 minutes) |
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Merrem (Meropenem)
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More stable in NaCl than dextrose (see
below)
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Dilute to concentration of 2.5-50mg/ml
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Infuse over 15-30 minutes
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In saline, 50mg/ml stable 2hours at room temp or
12hours under refrigeration
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In saline, 2.5-20mg/ml stable 4 hours at room
temp or 24 hours under refrigeration
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In dextrose, 2.5-20mg/ml stable 1 hour at room
temp or 6 hours under refrigeration
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| Mesnex (Mesna) |
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Compatible in dextrose and NaCl |
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May be given by injection or infusion |
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Usually given over 15-30 minutes
but may be given by continuous infusion |
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Dilute infusion to 20mg/ml |
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Multidose vials stable for 8 days in fridge |
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| Natrecor (6mcg/ml) (Nesiritide) |
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Bolus: weight (kg)/3 = ml of bolus |
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Infusion: weight (kg)*0.1 = ml/hr |
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Mix 1.5mg in 250ml of
fluid to make final concentration of 6mcg/ml |
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Compatible in dextrose and NaCl |
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Stable for 24 hours
at room temp or in fridge |
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Dosing Calculator |
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Dosing
Protocol |
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| Neosynephrine (Phenylephrine) |
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***Protect from light*** |
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Compatible in dextrose and NaCl |
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May be mixed in
concentrations of 0.02-1mg/ml (0.02mg/ml is 10mg in 500ml) |
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Stable for at least
48 hours at room temperature |
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Dosing Protocol |
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| Nipride (Nitroprusside) |
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***Protect from light*** |
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Compatible with dextrose |
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DO NOT mix in NaCl;
it will break down into cyanide (That's Bad!!!) |
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Mix 50mg in 250-1000ml of D5W |
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Stable for 24 hours at room temperature |
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Dosing Calculator |
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Dosing
Protocol |
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| Nitroglycerin |
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Compatible in dextrose and NaCl |
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Stable for 48 hours
at room temp or 7 days under refrigeration |
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Mix 50mg in 250ml (200mcg/ml) |
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Do not exceed 400mcg/ml |
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Must be mixed in glass |
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Dosing Calculator |
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Dosing Protocol |
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| Norcuron (Vecuronium) |
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Compatible in dextrose and NaCl |
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Mix in a concentration of 0.1-0.2mg/ml |
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Stable for 24 hours |
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Should
be refrigeration after reconstitution if not being used |
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| Pentamidine (Pentam) |
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Compatible in dextrose and NaCl |
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Mix in 50 to 250ml of fluid |
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Run over 60 to 120 minutes |
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Stable for 48 hours at room temperature |
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Dose: 4mg/kg once daily for 14-21 days |
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| Precedex (Dexmedetomidine) |
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Compatible in
dextrose and NaCl |
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Dilute 2ml (200mcg)
in 48ml of 0.9% NaCl (4mcg/ml) |
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Stable for 48 hours
at room temperature |
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Dosing
Protocol |
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| Primacor (Milrinone) |
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Available as
200mcg/ml premix |
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Compatible with
dextrose and NaCl |
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Stable for at least
14 days |
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Dosing
Protocol |
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Primaxin (Imipenem-Cilastatin)
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Compatible in NaCl |
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Do not exceed concentration of 5mg/ml
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Infuse each 500mg over at least 30 minutes
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Stable for 4 hours at room temp or 24 hours under
refrigeration |
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| Pronestyl (Procainamide) |
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Compatible with NaCl |
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Mix in a concentration of 2-4mg/ml |
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Stable for 24 hours at room temp
or 7 days under refrigeration |
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Do not exceed 50mg/min |
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| Protamine |
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Compatible with NaCl and Dextrose |
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Stable for at least 10 days at room temperature |
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May be given undiluted or as an
infusion |
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Do not give any faster than 50mg per 10 minutes |
|
May cause severe hypotension and
bradycardia. Patients who are having cardiovascular |
|
symptoms already may need the drug to be administered slower
(i.e. 50mg per hour) |
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Dosing
Protocol |
|
| Refludan (Lepirudin) |
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Compatible in dextrose and NaCl |
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For bolus, dilute one 50mg vial with 10ml to make 5mg/ml and
push over 15-20 seconds |
|
For drip, dilute to a concentration of 0.2-0.4mg/ml
(50-100mg in 250ml bag) |
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Stable for 24 hours |
|
aPTT ratio (aPTT/midpoint of lab normal range) target is
1.5-2.5 |
|
aPTT should be checked every 4 hours until aPTT ratio
1.5-2.5, then every 24 hours |
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Dosing Calculator |
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Dosing
Protocol |
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| Regitine (Phentolamine) |
|
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10mg diluted with
10ml 0.9% NaCl and inject into the affected area for extravasation of
catecholamines |
|
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such as
norepinephrine, epinephrine, and dopamine |
|
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| Retavase (Reteplase) |
|
|
|
Dilute 10.4 unit vial
with 10ml of water to make 1 unit/ml (DO NOT SHAKE) |
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Must be used within 4
hours of mixing |
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Dose (MI): 10 units
over 2 minutes x 2 doses 30 minutes apart |
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Dosing Calculator |
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| Sandostatin (Octreotide) |
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***Protect from light*** |
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Stored under refrigeration but
may be stored for up to 14 days at room temperature |
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Compatible in dextrose and NaCl |
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May be mixed in
50-200ml and infused over 15-30 minutes |
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Dose: (Esophageal
Varices) 50mcg bolus followed by 25-50mcg/hr |
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Dosing Protocol |
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| Synagis (Palivizumab) |
|
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Dose: 15mg/kg once monthly
during RSV season (roughly November through April) |
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50mg vial - add 0.6ml of sterile
water, 50mg = 0.5ml |
|
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100mg vial - add 1.0ml of
sterile water, 100mg = 1.0ml |
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Use within 6 hours of reconstitution |
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| Theophylline Drip
(Aminophylline) |
|
|
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Max rate 20mg/min |
|
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Loading dose 6mg/kg over 20-30 minutes |
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(Only load if patient
is not taking Theophylline) |
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Theophylline
available as premix as 400mg (equivalent to 500mg aminophylline) in 500ml
D5W |
|
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Also stable in 0.9%
NaCl for at least 24 hours |
|
| |
Mix with 500mg in
500ml to make a 1mg/ml (aminophylline)(Theophylline premix is of
equivalent concentration) |
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Dosing Calculator |
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Dosing Protocol |
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Loading dose (Only load if patient is not taking
Theophylline): 6mg/kg over 20-30 minutes |
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Maintenance Dose: |
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For 12 Hours following bolus |
Maintenance dose following 12
hours |
|
6 months - 9 years |
|
1.2mg/kg/hr |
1mg/kg/hr |
|
9-16 years |
|
1mg/kg/hr |
0.8mg/kg/hr |
|
Young adult smoker |
|
1mg/kg/hr |
0.8mg/kg/hr |
|
Nonsmoking adult |
|
0.7mg/kg/hr |
0.5mg/kg/hr |
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Elderly |
|
0.6mg/kg/hr |
0.3mg/kg/hr |
|
Cor Pulmonale Pt. |
|
0.6mg/kg/hr |
0.3mg/kg/hr |
|
CHF or Liver Failure |
|
0.5mg/kg/hr |
0.1-0.2mg/kg/hr |
|
***Doses are based on Aminophylline, NOT
Theophylline |
|
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| TNKase (Tenecteplase) |
|
|
|
Dilute 50mg vial with
10ml to make 5mg/ml |
|
|
Must be used within 8
hours of mixing |
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Give IV push over 5
seconds |
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