Drugs Requiring Reconstitution
Drug Add listed volume Final Concentration Stability at Room Temp Stability Under Refrigeration Other Information
Acetazolamide (Diamox) 500mg 5ml 100mg/ml 12 hours 3 days  
Acyclovir (Zovirax) 1000mg 20ml 50mg/ml 12 hours n/a Do not Refrigerate
Acyclovir (Zovirax) 500mg 10ml 50mg/ml 12 hours n/a Do not Refrigerate
Alteplase (Activase) 100mg 100ml 1mg/ml 8 hours 8 hours Stable at least 6 months frozen
Alteplase (Activase) 50mg 50ml 1mg/ml 8 hours 8 hours Stable at least 6 months frozen
Amphotericin B Liposome (Ambisome) 50mg 12ml 4mg/ml n/a 6 hours 4mg/ml in vial stable for 24 hours in fridge
Ampicillin 1000mg 3.5ml 250mg/ml 8 hours 72 hours Stability is only at 20mg/ml in 0.9% NaCl
Ampicillin 125mg 1.2ml 125mg/ml 8 hours 72 hours Stability is only at 20mg/ml in 0.9% NaCl
Ampicillin 2000mg 6.8ml 250mg/ml 8 hours 72 hours Stability is only at 20mg/ml in 0.9% NaCl
Ampicillin 250mg 1ml 250mg/ml 8 hours 72 hours Stability is only at 20mg/ml in 0.9% NaCl
Ampicillin 500mg 1.8ml 250mg/ml 8 hours 72 hours Stability is only at 20mg/ml in 0.9% NaCl
Ampicillin/Sulbactam (Unasyn) 1.5gm 4.2ml 300mg/ml 72 hours n/a Stability is only at 30mg/ml in 0.9% NaCl
Ampicillin/Sulbactam (Unasyn) 3gm 8.4ml 300mg/ml 72 hours n/a Not very stable in dextrose
Azithromycin (Zithromax) 500mg 4.8ml 100mg/ml 24 hours 7 days  
Aztreonam (Azactam) 1gm 10ml 100mg/ml 48 hours 7 days  
Aztreonam (Azactam) 2gm 20ml 200mg/ml 48 hours 7 days  
Cefazolin (Ancef) 10gm 45ml 200mg/ml 24 hours 4 days 10gm only stable 4 hours in the vial
Cefazolin (Ancef) 1gm 4.5ml 200mg/ml 24 hours 4 days  
Cefotaxime (Claforan) 1gm 4.6ml 200mg/ml 24 hours 5 days  
Cefotetan (Cefotan) 1gm 9.5ml 100mg/ml 24 hours 96 hours  
Cefotetan (Cefotan) 2gm 19ml 100mg/ml 24 hours 96 hours  
Cefoxitin (Mefoxin) 1gm 9.5ml 100mg/ml 18 hours 48 hours  
Cefoxitin (Mefoxin) 2gm 19ml 100mg/ml 18 hours 48 hours  
Ceftazidime (Fortaz) 1gm 9.4ml 100mg/ml 24 hours 7 days  
Ceftazidime (Fortaz) 2gm 8.5ml 200mg/ml 24 hours 7 days  
Ceftazidime (Fortaz) 6gm 26ml 200mg/ml 24 hours 7 days  
Ceftriaxone 1000mg 3.6ml 250mg/ml 2 days 10 days  
Ceftriaxone 2000mg 7.2ml 250mg/ml 2 days 10 days  
Ceftriaxone 250mg 0.9ml 250mg/ml 2 days 10 days  
Ceftriaxone 500mg 1.8ml 250mg/ml 2 days 10 days  
Cefuroxime (Zinacef) 1500mg 14.4ml 10mg/ml 24 hours 7 days  
Cefuroxime (Zinacef) 750mg 7.2ml 10mg/ml 24 hours 7 days  
Chloramphenicol (Chloromycetin) 1gm 10ml 100mg/ml 30 days n/a  
Chlorothiazide (Diuril) 500mg 20ml 25mg/ml Use Immediately  
Cosyntropin (Cortrosyn) 0.25mg 1ml 0.25mg/ml 24 hours 21 days Note: Stability of 1ml dliution
Deferoxamine (Desferal) 2000mg 20ml 100mg/ml Use Immediately  
Deferoxamine (Desferal) 500mg 5ml 100mg/ml Use Immediately  
Doxycycline (Vibramycin) 100mg 10ml 1mg/ml 48 hours 72 hours ***Protect from light***
Ertapenem (Invanz) 1gm 10ml 100mg/ml 6 hours 24 hours Use within 4 hours of taking out of fridge
Ethacrynic Acid (Edecrin) 50mg 50ml 1mg/ml 24 hours n/a  
Hydrocortisone (Solu-Cortef) 1gm 8ml 125mg/ml 3 days n/a ***Protect from light***
Imipenem - Cilastatin 500mg 9.6ml 50mg/ml 4 hours 24 hours  
Indomethacin (Indocin) 1mg 1ml 0.1mg/ml Use Immediately  
Leukovorin 100mg/ml 10ml 10mg/ml n/a 7 days ***Protect from light***
Leukovorin 350mg/ml 34.5ml 10mg/ml n/a 7 days ***Protect from light***
Leukovorin 350mg/ml 17ml  20mg/ml n/a 7 days ***Protect from light***
Levothyroxine 200mcg 5ml 40mcg/ml Use Immediately ***Protect from light***
Levothyroxine 500mcg 5ml 100mcg/ml Use Immediately ***Protect from light***
Meropenem 500mg 10ml 50mg/ml 2 hours 12 hours stability in saline at 50mg/ml
Meropenem 500mg 10ml 50mg/ml 4 hours 24 hours stability in saline at 2.5-20mg/ml
Methylprednisolone (Solu-Medrol) 2gm 19.4ml 100mg/ml 48 hours n/a ***Protect from light***
Nafcillin 10gm 93ml 100mg/ml 24 hours 7 days  
Nafcillin 1gm 9.4ml 100mg/ml 24 hours 7 days  
Nafcillin 2gm 18.6ml 100mg/ml 24 hours 7 days  
Oxacillin 10gm 47.5ml 200mg/ml see below  
Oxacillin 1gm 4.7ml 200mg/ml see below  
Oxacillin 2gm 9.5ml 200mg/ml see below  
Oxacillin mixed in Dextrose --- --- 6 hours 4 days  
Oxacillin mixed in NaCl --- --- 4 days 7 days  
Palivizumab (Synagis) 50mg 0.6ml 100mg/ml 6 hours n/a  
Palivizumab (Synagis) 100mg 1ml 100mg/ml 6 hours n/a  
Pamidronate (Aredia) 30mg 10ml 3mg/ml n/a 24 hours  
Pamidronate (Aredia) 90mg 10ml 9mg/ml n/a 24 hours  
Pantoprazole (Prevacid) 5ml 6mg/ml 24 hours 24 hours  
Penicillin G 1,000,000 units 3.8ml 250,000u/ml n/a 7 days  
Penicillin G 5,000,000 units 18ml 250,000u/ml n/a 7 days  
Pentamidine (Pentam) 300mg 3ml 100mg/ml 48 hours n/a  
Pipercillin/Tazobactam (Zosyn) 3.375gm 17ml  3.375gm/20ml 24 hours 48 hours  
Pipercillin/Tazobactam (Zosyn) 4.5gm 17ml  4.5gm/20ml 24 hours 48 hours  
Tenecteplase (TNKase) 50mg 10ml 5mg/ml n/a 8 hours  
Tobramycin (Nebcin) 1.2gm 30ml 40mg/ml 24 hours 96 hours  
Vancomycin (Vancocin) 1000mg 20ml 50mg/ml 14 days 14 days  
Vancomycin (Vancocin) 500mg 10ml 50mg/ml 14 days 14 days  
Vecuronium (Norcuron) 10mg 10ml 1mg/ml 24 hours n/a  
Vecuronium (Norcuron) 20mg 20ml 1mg/ml 24 hours n/a  
Voriconazole (Vfend) 200mg 19ml 10mg/ml 14 days n/a  
*** Stability is that of an IV solution, not that diluted drug in the vial unless otherwise noted